IV Simpósio de Planejamento e Desenvolvimento de Fármacos para Doenças Negligenciadas

Pharmacist graduated at Federal University of Paraiba (UFPB), Master in Pharmaceutical Sciences, Federal University of Pernambuco (UFPE). Since 2007, she is an Industry Pharmacist of Pharmaceutical Laboratory of Pernambuco (LAFEPE), working on Research & Development Department. Besides that, she is a tutor of Bachelor of Pharmacy at Faculdade Pernambucana de Saúde, since 2011.

Federal University of Pernambuco

Pharmacist graduated at State University of São Paulo (UNESP), Master in Pharmacology at the School of Medicine of Ribeirão Preto – University of São Paulo (FMRP-USP) and PhD in Drug and Medicines at School of Pharmaceutical Sciences – University of São Paulo (FCF-USP). Currently, she is Associate Professor in Medicinal Chemistry at School of Pharmaceutical Sciences – UNESP, Araraquara. She has experience in the design and synthesis of drugs and prodrugs with antimicrobial and anti-inflammatory activities. In addition, she has been working on neglected diseases, especially Chagas Disease. She is coordinator of Lapdesf - Laboratory of Drug Design at FCF/UNESP, coordinator and lecturer of the course "Pharmacotherapy and Drug Interactions" for professional updating at AFAR and invited professor of specialization course in Pharmaceutical Care at the Federal University of Alfenas.

University of Dundee

Professor at the Department of Pharmaceutical Sciences at Federal University of Pernambuco, member of the Graduate Program in Pharmaceutical Sciences (PPGCF), Graduate Program in Therapeutic Innovation (PPGIT) and production manager of the Brazilian Foundation of Blood derivatives (HEMOPE). She has experience in the field of Medicinal Chemistry, her research is focusing on the following topics: design and synthesis of new bioactive molecules, especially on synthesis of thiosemicarbazones, 4-thiazolidones, phthalimide, 1,2,4-oxadiazoles for antitumour, anti-T. cruzi, anti-inflammatory and antimicrobial activities.

Federal University of Pernambuco

Degree in Pharmacy and Biochemistry (1997) (School Oswaldo Cruz.), Master in Biological Applications of Nuclear Technology-IPEN-USP (1999), PhD in Biology of Host-Pathogen Interactions - ICB-USP (2003), with part of the Ph.D. at the London School of Hygiene And Tropical Medicine (2001), post-doctorate at UNIFESP. Scientific researcher level VI of the Adolfo Lutz Institute, coordinator of the Laboratory Novel Drugs-Neglected Diseases Drugs (ND-ND-Lab) and deputy director of the Center for Parasitology and Mycology. Advisor and deputy coordinator of the Post-Graduation Program of the Secretary of Health of São Paulo State and coordinator of the Program Laboratory Research in Public Health. Supervisor of Tropical Medicine Post-Graduation Program, University of São Paulo. Integrates the research network ResNet NPND (Brazil-Germany-Universität Münster) in neglected diseases. Coordinates projects in the area of new drugs for neglected diseases (leishmaniasis and Chagas disease) with international partners including universities such as Ohio State (USA), Dundee (Scotland), King's College London, Bangor (UK), Munster (Germany) and Auckland (New Zealand). Coordinated by four years a public-private partnership with the pharmaceutical company GlaxoSmithKline (UK) for preclinical studies in visceral leishmaniasis. Field of interest- Drug Discovery & Delivery, with emphasis on pre-clinical studies of the effectiveness of drugs, mechanism of action of drugs, DMPK in silico and in vivo, repositioning of drugs, combination therapy, isolation of "small molecules" of natural products as new prototypes.

Adolfo Lutz Institute, University of São Paulo

PhD in Organic Chemistry at University of Sao Paulo in 1973. Currently, she is an Associate Professor at University of Sao Paulo (USP). She works on ​​Chemistry and Pharmacy areas, with emphasis on Medicinal Chemistry. She has three patent claims and several collaborations in Brazil and abroad, especially with German researchers. Honored Professor by graduates of 2011 and 2012 from School of Pharmaceutical Sciences, USP. In 2008, she won Cutting-edge researcher Award from Division of Medicinal Chemistry/Brazilian Chemical Society. She has a Productivity Grants in the Brazilian National Research Council (CNPq).

University of Sao Paulo

Adjunct Professor at Faculty of Pharmacy, Federal University of Goias, and head of LabMol – Laboratory for Molecular Modeling and Drug Design. She graduated in Pharmacy and got her PhD on Drugs and Medicines at University of Sao Paulo (USP), with part of her PhD developed at the University of New Mexico, USA. Her research focuses on Drug Design for Neglected Diseases and Cancer, using integrated Virtual Screening (VS) approaches, QSAR models and cheminformatics and chemogenomics approaches to identify new hit compounds for these diseases. Her group is also focused on the generation of predictive tools to study Metabolism and Toxicity of chemical compounds. In 2014, she was awarded with the “For Women in Science” award from L’Oréal Brasil- UNESCO-ABC, and in 2015, she received the “International Rising Talents” award from L’Oréal – UNESCO. Since 2012, she is CNPq research fellow – 2 level, and is the treasurer of the Division of Medicinal Chemistry of the Brazilian Chemical Society (SBQ) (2014-2016).

Federal University of Goias

Graduated in Electronic Engineering from ITA in 1978. Obtained the title of Master of Science in 1980 and the Doctor of Sciences in 1983, at the Institute of Physics Gleb Wataghin, Unicamp. He was a visiting researcher at the Università degli Studi in Rome, visiting researcher at the Université Pierre et Marie Curie, Paris, and a resident visitor at Bell Laboratories of AT&T in Holmdel, NJ and in Murray Hill, NJ. His research is in ultrafast phenomena using ultra-short laser pulses, with emphasis on the study of electronic processes in the time-scale of femtoseconds in nonlinear optical materials aimed for applications in optical communications. Brito Cruz was Director of the Physics Institute Gleb Wataghin, Unicamp and the Dean for Research at Unicamp. He has been the Vice President of the Brazilian Society of Physics and member of the Advisory Board of the International Optical Society of America. He is a member of the Brazilian Academy of Sciences. He was President of the São Paulo Research Foundation, FAPESP, from 1996 to 2002 and Rector of Unicamp from April 2002 to April 2005. He has been the President of the Board of Technology and Competitiveness of FIESP (2005-2012). Since April 2005, Brito Cruz is the Scientific Director of FAPESP.

State University of Campinas

Pharmacist graduated at State University of São Paulo (UNESP), Master in Pharmacology at the School of Medicine of Ribeirão Preto – University of São Paulo (FMRP-USP) and PhD in Drug and Medicines at School of Pharmaceutical Sciences – University of São Paulo (FCF-USP). Currently, she is Associate Professor in Medicinal Chemistry at School of Pharmaceutical Sciences – UNESP, Araraquara. She has experience in the design and synthesis of drugs and prodrugs with antimicrobial and anti-inflammatory activities. In addition, she has been working on neglected diseases, especially Chagas Disease. She is coordinator of Lapdesf - Laboratory of Drug Design at FCF/UNESP, coordinator and lecturer of the course "Pharmacotherapy and Drug Interactions" for professional updating at AFAR and invited professor of specialization course in Pharmaceutical Care at the Federal University of Alfenas.

State University of São Paulo

Eliezer J. Barreiro is a Pharmacist graduated at Federal University of Rio de Janeiro (1970), Master in Chemistry of Natural Products at Federal University of Rio de Janeiro (1973) and Docteur d´Ètat in Chimie Médicale from Université de Grenoble I (Université Scientifique et Médicale - Joseph Fourier, Université de Grenoble, France) (1978). Currently, he is Full Professor of Medicinal Chemistry at Federal University of Rio de Janeiro (UFRJ, Brazil) and author of more than 300 papers and 15 patents. His research subjects are Medicinal Chemistry, Design and Synthesis of New Lead-compounds, Molecular Modeling and Dynamics, Synthesis of Bioactive Compounds, in particular N-acylhydrazone (NAH) derivatives and isosteres. He is the Scientific Coordinator of National Institute of Science and Technology in Drugs and Medicines (INCT-INOFAR), the founder and Scientific Director of Laboratório de Avaliação e Síntese de Substâncias Bioativas (LASSBio) of Federal University of Rio de Janeiro and full member of Brazilian Academy of Science since 2001. In 2010, he was awarded as Oficial Grã Cruz from National Order of Scientific Merit of the Presidency of Brazil.

Federal University of Rio de Janeiro

Pharmacist-biochemist, Faculty of Pharmaceutical Sciences, University of Sao Paulo, Doctor in Sciences, Organic Chemistry, Institute of Chemistry, University of Sao Paulo, Short Post-Doctorate on Molecular Modeling, with Anton J. Hopfinger, University of Illinois at Chicago, USA. Full Professor, Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo. Coordinator of the Graduate Program on Drugs and Medicines, Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of Sao Paulo, from 2002 to 2014. Head of Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, since 2014. Scientific Editor of Brazilian Journal of Pharmaceutical Sciences. Working on Drug Design of New Chemotherapeutic Agents against Neglected Diseases: Chagas disease, malaria, leishmaniasis and tuberculosis, using prodrug design and rational drug design approaches. Recently working on dendrimer prodrugs with potential activity in neglected diseases.

University of Sao Paulo

Pharmacist graduated at School of Pharmaceutical Sciences of Ribeirão Preto , University of São Paulo (FCFRP-USP) (1979), Master in Drug and Medicines at School of Pharmaceutical Sciences, University of São Paulo (FCF-USP) (1987), PhD in Organic Chemistry at the Institute of Chemistry, University of São Paulo (IQ-USP) (1991), postdoctoral in Carbohydrates Chemistry at University of East Anglia (UEA-England) (1997) and in Glycopeptides Chemistry at University of Saint Andrews (Scotland) (2001). Currently, she is Full Professor at School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo (FCFRP-USP). She has experience in Medicinal Chemistry with emphasis on Synthesis and Structure-activity relationships of bioactive compounds, regarding on: Chagas’ disease, synthesis of natural products (carbohydrates, glycopeptides, phospholipids, nucleosides and neolignans derivatives) and aminoglycosides antibiotics.

University of São Paulo

His background is in molecular biology of microorganisms with specific training and expertise in drug discovery and development for neglected tropical diseases. He was pioneer in the development of high-content screening assays against intracellular Trypanosoma cruz’and Leishmania sp, having screened over 1,000,000 chemical entities to date against parasites. Currently as Assistant Adjunct Professor at UCSD, and Kinetoplastid Core Director at the highly collaborative Center for Discovery and Innovation in Parasitic Diseases (CDIPD), his mission is to discover better treatment options for those affected by neglected diseases, specially Chagas disease, leishmaniasis and Human African Trypanosomiasis. He has designed and supervised the construction of the High Throughput Screening Platform located in the fourth floor of the Skaggs School of Pharmacy and Pharmaceutical Sciences, UCSD. His research interests include: 1) development of relevant high-throughput and high-content screening assays to identify active compounds against parasites; 2) advance identified hits to lead series by optimizing its pharmacokinetics and pharmacodynamics properties through medicinal chemistry; 3) development and improvement of animal models for parasitic diseases for in vivo antiparasitic efficacy assessment. Aligned with these subjects, he has experience collaborating with pharmaceutical companies, exemplified by a project with Genomics Institute of the Novartis Research Foundation (GNF) funded by an R01 grant, with a recent publication under his correspondence. He has also lead a team of graduate students from Stanford University and UC Berkeley to develop a Startup (SolPaDis) with the mission to design an innovative and sustainable approach to develop new chemotherapies against neglected diseases following the Lean LaunchPad method, mentored by Steve Blank and Karl Handelsman. In summary, He has a demonstrated record of accomplished and productive research applying innovative and cutting-edge technology in the field of tropical diseases drug discovery and development.

Skaggs School of Pharmacy and Pharmaceutical Sciences

Degree in Pharmacy and Biochemistry (1997) (School Oswaldo Cruz.), Master in Biological Applications of Nuclear Technology-IPEN-USP (1999), PhD in Biology of Host-Pathogen Interactions - ICB-USP (2003), with part of the Ph.D. at the London School of Hygiene And Tropical Medicine (2001), post-doctorate at UNIFESP. Scientific researcher level VI of the Adolfo Lutz Institute, coordinator of the Laboratory Novel Drugs-Neglected Diseases Drugs (ND-ND-Lab) and deputy director of the Center for Parasitology and Mycology. Advisor and deputy coordinator of the Post-Graduation Program of the Secretary of Health of São Paulo State and coordinator of the Program Laboratory Research in Public Health. Supervisor of Tropical Medicine Post-Graduation Program, University of São Paulo. Integrates the research network ResNet NPND (Brazil-Germany-Universität Münster) in neglected diseases. Coordinates projects in the area of new drugs for neglected diseases (leishmaniasis and Chagas disease) with international partners including universities such as Ohio State (USA), Dundee (Scotland), King's College London, Bangor (UK), Munster (Germany) and Auckland (New Zealand). Coordinated by four years a public-private partnership with the pharmaceutical company GlaxoSmithKline (UK) for preclinical studies in visceral leishmaniasis. Field of interest- Drug Discovery & Delivery, with emphasis on pre-clinical studies of the effectiveness of drugs, mechanism of action of drugs, DMPK in silico and in vivo, repositioning of drugs, combination therapy, isolation of "small molecules" of natural products as new prototypes.

Extended Executive Team at DNDi

Pharmacist, graduated at Federal University of Paraiba and Ph.D in Drug and Medicines at the University of São Paulo. Since 1986, Tavares he is professor at the School of Pharmaceutical Sciences, University of São Paulo and has taught the following subjects: Industrial Pharmaceutical Achievement, Biochemical Pharmaceutical Technology, Structure-Activity Relationships of Drugs, Pharmacy History, Health and Society, Optimization of Drugs and Biochemical Pharmaceutical Technology Topics. Currently he is Full Professor of the Department of Biochemical and Pharmaceutical Technology, and member at National Academy of Pharmacy. He has experience in drug design and development, mainly about antimicrobial, antichagasic and radiopharmaceuticals for PET/SPEC image in CNS.

University of São Paulo

Pharmacist and PhD in Chemistry at the Federal University of Rio de Janeiro (UFRJ). Post-doctoral internship in Medicinal chemistry at University of Navarra (UNAV, Pamplona, Spain). Currently she is Associate Professor at Biomedical Sciences Institute (ICB), UFRJ and CNPq researcher level 2. Scientific Superintendent of National Institute of Science and Technology in Drugs and Medicines (INCT-INOFAR). Coordinator of Research Program in Drug Development and Deputy Coordinator of Graduate Program in Pharmacology and Medicinal Chemistry (ICB-UFRJ). She has experience in Drug Design, mainly about anti-inflammatory, chemotherapeutical agents (antichagasic, leishmanicidal and antineoplasic), oral hypoglycemic and in silico studies of metabolism and druglikeness properties.

Federal University of Rio de Janeiro

Undergraduate in chemical at Federal University of Santa Catarina and PhD in Chemistry at the State University of Campinas (UNICAMP). Post-doctoral internship in chemical at Harvard University. Since 1992, Dias is professor at Chemistry Institute, UNICAMP. Currently he is Full Professor and CNPq researcher level 1A. He has published over 100 articles/ texts/ interviews. His laboratory was accredited by World Health Organization as World Reference Center for synthesis of antichagasic compounds. Dias is Full Member at Sciences Academy of São Paulo State, Comander at National Order of Scientific Deserving, Full Member at Brazilian Academy of Sciences, Honorary Member at Argentina Society of Organic Chemistry, Investigation Fellow at International union of Pure and Applied Chemistry and Fellow at Royal Society of Chemistry. He has experience in Organic Chemistry, mainly about total synthesis of bioactive compounds, relative stereochemistry control in acyclic systems and theoretical chemistry.

State University of Campinas

Chemical engineer graduated at Polytechnic School at University of São Paulo (USP) (1999), specialized in Industrial Management at Carlos Alberto Vanzolini Foundation (2002), Master in Organic Chemistry at University of São Paulo (2005), PhD in Organic Chemistry at University of São Paulo (2008) and Postdoctoral at Nova de Lisboa University (2014). Currently, he is Associate Professor at Federal University of Paraíba, grant projects referee for National Council for Scientific and Technological Development (CNPq) and referee for many journals of pharmaceutical field. He has experience in Chemistry, with emphasis on Organic Chemistry, regarding on molecular descriptors, neural networks, taxonomy, chemometrics, biological activity and molecular modeling.

Federal University of Paraíba

Biologist graduated at Pedro II Faculty of Humanitiy (1985), Master in Parasitic Biology at Oswaldo Cruz Foundation (1992) and PhD in Molecular and Cell Biology at Oswaldo Cruz Foundation (1999). Currently, she is Full Professor of Oswaldo Cruz Foundation, grant projects referee for National Council for Scientific and Technological Development (CNPq) and referee of many journals of Pharmaceutical field. She has experience in Parasitology, with emphasis on Protozoology of Parasites. Her research is focused on the following subjects: Trypanosoma cruzi, cardiomiocytes, Chagas disease, chemotherapy and apoptosis.

Oswaldo Cruz Foundation

Pharmacist graduated at Lyceum Alpinum Zuoz (1967). PhD in Biology/Neuroscience at University of Zuerich (1975) and Postdoctor in Neurophysiology and Pharmacology at University of California (1978). Paul Herrling was head of global research at Sandoz Pharma (1994-1996) and Novartis (1996-2002). Currently, he is Chairman at Novartis Institute for Tropical Diseases, Vice President of the Board of the Swiss Federal Institutes of Technology. Paul Herrling is also Professor of Drug Discovery Science at the University of Basel, Switzerland, and Full Adjunct Professor at the Harold Dorris Neurobiological Institute, Scripps Research Institute, La Jolla, California.

Novartis Institute for Tropical Diseases, University of Basel

Graduated in Electronic Engineering from ITA in 1978. Obtained the title of Master of Science in 1980 and the Doctor of Sciences in 1983, at the Institute of Physics Gleb Wataghin, Unicamp. He was a visiting researcher at the Università degli Studi in Rome, visiting researcher at the Université Pierre et Marie Curie, Paris, and a resident visitor at Bell Laboratories of AT&T in Holmdel, NJ and in Murray Hill, NJ. His research is in ultrafast phenomena using ultra-short laser pulses, with emphasis on the study of electronic processes in the time-scale of femtoseconds in nonlinear optical materials aimed for applications in optical communications. Brito Cruz was Director of the Physics Institute Gleb Wataghin, Unicamp and the Dean for Research at Unicamp. He has been the Vice President of the Brazilian Society of Physics and member of the Advisory Board of the International Optical Society of America. He is a member of the Brazilian Academy of Sciences. He was President of the São Paulo Research Foundation, FAPESP, from 1996 to 2002 and Rector of Unicamp from April 2002 to April 2005. He has been the President of the Board of Technology and Competitiveness of FIESP (2005-2012). Since April 2005, Brito Cruz is the Scientific Director of FAPESP.

Director at Medicines for Malaria Venture

Assistant professor at Physics Institute of São Carlos (IFSC), University of São Paulo (USP). He received his PhD in biomolecular physics from University of São Paulo and University of Marburg in 2008, and worked two years like a postdoctoral researcher in Medicinal Chemistry and Structural Biology at University of São Paulo. He is a specialist in structure-based drug design and in the integration of computational and experimental methods. His research is focused on the structural elucidation of relevant molecular targets and the application of this knowledge toward the discovery and development of new drugs and agrochemicals for human and plant diseases. He is Vice-Director of the Division of Medicinal Chemistry of the Brazilian Chemical Society (SBQ), and Affiliated Member of the The World Academy of Sciences (TWAS) (2105-2020). He is associate investigator of the National Institute of Structural Biotechnology and Medicinal Chemistry in Infectious Diseases (INBEQMeDI-INCT-CNPq-FAPESP) as well as Center for Research and Innovation in Biodiversity and Drugs (CIBFar-CEPID-FAPESP).

Physics Institute of São Carlos, University of São Paulo

Pharmacist graduated at Federal University of Minas Gerais and PhD in Chemistry and Chemical Biology at University of California, San Francisco. Besides that, she was a postdoctoral researcher at University of São Paulo. Currently, she is a Professor at Biochemistry and Immunology Department, Federal University of Minas Gerais. Her research is focused on drug design, enzymology and structural biology, especially towards the development of parasitic cysteine protease inhibitors.

Federal University of Minas Gerais

Graduated on Bachelor of Arts in Chemistry at Rutgers University, New Brunswick (2002), Silvia Gonzalez worked as Chemistry Tutor at Rutgers University (1999-2002). Also worked as Medicinal Chemistry Scientist at Merck (2002-2003). Currently, Silvia Gonzalez worked as Principal Scientist at GlaxoSmithKline (GSK) on the projects: Diseases of Developing World (Tres Cantos, Spain), Malaria, on Malaria Medicine Venture (2003-2005), Tuberculosis, Global Alliance for TB (2005-2011).

Rutgers University

Colli is a Medical Doctor (1962), Ph.D. in Biochemistry (1966, School of Medicine, University of São Paulo, USP) and Privat-Dozent (1971, Institute of Chemistry, Department of Biochemistry, USP), presently Full Professor of Biochemistry since 1980.  He was Director (Dean) of the Institute of Chemistry for two terms (1986-1990 and 1994-1998), the Butantan Institute (the Snake Farm, 1999) and the International Relations Institute, IRI, from the University of São Paulo (2005-2009). He was a member of the Deliberative Council of the National Research Council of Brazil (CNPq 1989-1991), of the Higher Council of the São Paulo State Foundation for the Support of Research, (FAPESP, 1988-1994), and the President of the Brazilian Biosafety Committee, CTNBio, since 2006, for a 4 year term. He was also the Director General of the Brazilian Association of Synchrotron Light Technology (ABTLuS/CNPEM, 06/2010 – 05/2011). He is an Associate Coordinator of FAPESP Scientific Director since 2003. Due to his intense collaboration with Argentinean scientists for 30 years and training of several post-doctoral fellows from Argentina he was awarded with the title of Doctor Honoris Causa from the University of Buenos Aires. He is a permanent member of the Brazilian Academy of Sciences and of the Academy of Sciences of the Developing World (TWAS), and a member of the Scientific Merit Order of Brazil, granted by the President of Brazil. In 2014 he was awarded the Almirante Álvaro Alberto Prize for Science and Technology. He has experience in Biochemistry and Molecular Biology working with the interaction between Trypanosoma cruzi, the agent of Chagas’ disease, and the host-cell, with particular focus on plasma membrane glycoconjugates, ligand­­­­­s and receptors. He has published 120 papers in the specialized literature as well as 20 book chapters, in addition to training the work of 23 Ph.D. students and post-docs.

Associate Coordinator of FAPESP Scientific Director